What is Tetrahydropyran-4-carboxylic acid?
Tetrahydropyran-4-carboxylic acid is a Pyran class chemical building Block and pharmaceutical intermediate.

Application of Tetrahydropyran-4-carboxylic acid

Tetrahydropyran-4-carboxylic acid can be used to synthetize (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides.
(4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides are useful in treating arthritis (osteoarthritis and rheumatoid arthritis included), inflammatory bowel disease, Crohn's disease, emphysema, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant toxicity, cachexia, allergic reactions, allergic contact hypersensitivity, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, osteoporosis, loosening of artificial joint implants, atherosclerosis (atherosclerotic plaque rupture included), aortic aneurysm (abdominal aortic aneurysm and brain aortic aneurysm included), congestive heart failure, myocardial infarction, stroke, cerebral ischemia, head trauma, spinal cord injury, both acute and chronic neuro-degenerative disorders, autoimmune disorders, Huntington's disease, Parkinson's disease, migraine, depression, peripheral neuropathy, pain, cerebral amyloid angiopathy, nootropic or cognition enhancement, amyotrophic lateral sclerosis, multiple sclerosis, ocular angiogenesis, corneal injury, macular degeneration, abnormal wound healing, burns, diabetes, tumor invasion, tumor growth, tumor metastasis, corneal scarring, scleritis, AIDS, sepsis and septic shock.
Additionally, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.