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武汉远成共创科技有限公司
替硝唑

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产品信息:

 替硝唑
中文同义词: 2-甲基-1-[2-(乙基磺酰基)乙基]-5-硝基-1H-咪唑;替硝唑;磺甲硝咪唑;TIXIAOZUO
性状:味微苦。本品在丙酮或氯仿中溶解,在水或乙醇中微溶。
用途:抗滴虫药,多用于妇科。替硝唑最先在美国研制成功,是继甲硝唑(metronidazole MNZ)后的新一代疗效更高、疗程更短、耐受性好、不良反应低的抗厌氧菌及抗滴虫的甲硝咪唑类药物。国际上广泛用于厌氧菌感染和原虫疾病的预防和治疗、优于甲硝唑。
药理作用:硝唑与甲硝唑同属硝基咪唑类。对原虫(溶组织阿米巴、阴道滴虫等)和厌氧菌有良好活性。对阿米巴和兰氏贾第虫的作用优于甲硝唑。革兰阳性厌氧菌(消化球菌、消化链球菌、乳杆菌属),梭状芽胞杆菌属和难辨梭菌等对该品均较敏感;该品对脆弱类杆菌、梭杆菌属和费氏球菌属等革兰阴性厌氧菌的作用略胜于甲硝唑,空肠弯曲菌等则对该品中度敏感。放线菌属和丙酸杆菌属等对该品耐药。其作用机制为抑制病原体DNA合成、并能快速进入细胞内。


Tinidazole
Synonym: TIMTEC-BB SBB006917;TINIDAZOLE;1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol;1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-imidazol;1-(2-(ethylsulfonyl)-ethyl)-2-methyl-5-nitroimidazole;bioshik;cp12574;ethyl(2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
CAS: 19387-91-8
MF: C8H13N3O4S
MW: 247.27
EINECS: 243-014-4
Assay: 99%
Appearance: white powder
Specification: CP
Chemical Property: Slightly bitter taste. This product is dissolved in acetone or chloroform, slightly soluble in water or ethanol.
Usage:
Drug resistance, multiple for gynecology. The first successful development of tinidazole in USA, following the metronidazole (metronidazole MNZ) of anaerobic bacteria in a new generation of high efficacy, period of treatment is shorter, good tolerance, low adverse reaction and Trichomonas metronidazole drugs. The widely used for anaerobic bacteria and protozoa disease prevention and treatment, is better than that of metronidazole.
Pharmacological effects:
ornidazole and metronidazole are nitroimidazole. (of protozoan Entamoeba histolytica, trichomonas) has good activity and anaerobic bacteria. For Amiba and Giardia lamblia effect is better than that of metronidazole. Gram positive anaerobic bacteria (peptococcus, Peptostreptococcus, Lactobacillus), fusiform bacillus and Clostridium difficile are more sensitive to the product; the product of Bacteroides fragilis, Fusobacterium and Fisher staphylococci and other gram negative anaerobic bacteria effect is slightly better than metronidazole, Campylobacter jejuni, the product is moderately sensitive. Actinomyces and Propionibacterium on the resistance. The mechanisms of inhibition of DNA synthesis, pathogens and can quickly enter the cells.
Package: 25kg/drum
Price: USD 24/kg

 

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替硝唑