非那西丁
中文同义词: 非那西汀;乙酰对氨基苯乙醚;乙酰乙氧基苯胺;对乙酰乙氧基苯胺;对乙酰氨基苯乙醚;非那西丁;醋酰氧乙苯胺;4-乙氧基乙酰苯胺
化学性质: 白色结晶性粉末。熔点137-138℃，折光率1.571。难溶于水，微溶于乙醚，略溶于沸水，溶于乙醇和氯仿。溶于浓硫酸时不显颜色，向溶液中滴入硝酸后即呈橙黄色。无臭，味微苦。
质量标准：BP
用途:
1. 解热镇痛药，用于治疗发热头痛、神经痛等
2. 解热镇痛药。非那西丁的解热镇痛作用与“乙酰水杨酸”相似，主要用作解热镇痛药，作用缓慢而持久，对治疗头痛、神经痛、关节痛和发热等都有较好疗效，但抗风湿、消炎作用较弱。剂量过大可导致高铁血红蛋白症，造成机体缺氧，长期用药可损害肾脏，甚至引起乳头坏死，应慎用。因其毒副作用和其他同类药物的迅速发展，该药已停止单独使用，只是作为原料药和其他药物配复方制剂。常与阿司匹林、咖啡因一起组成复方阿司匹林，其组成为非那西丁0.162克，阿司匹林 0.227克，咖啡因0.035克，毒性较小，用于治疗伤风感冒。如在上述药物中加入少量扑尔敏，还可制成扑尔敏感冒片，可用于治疗感冒头痛、神经痛、风湿痛等。
3. 非那西丁本身并无解热镇痛作用，在机体内，经过代谢分解出对乙酰氨基酚即扑热息痛，才发挥出解热镇痛的效果。还分解出对氨苯乙醚，对氨苯乙醚不但无解热镇痛作用，且是非那西丁毒副作用的主要因素。
中国于1954年开始生产非那西丁，由硝基氯苯与乙醇进行醚化反应得对硝基苯乙醚，再还原成对氨基苯乙醚后与乙酸进行乙酰化反应制得。

Phenacetin

Synonym: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Assay: 99%
Appearance: White crystal Powder
Specification: BP
Property: Insoluble in water, slightly soluble in ether, slightly soluble in water, soluble in ethanol and chloroform. Soluble in concentrated sulfuric acid to the solution without color, drip nitrate is orange yellow. No smell, taste slightly bitter.

Usage:
1. antipyretic analgesics for the treatment of fever, headache, neuralgia, etc.
2. antipyretic analgesic. Antipyretic and analgesic effects of non phenacetin and "aspirin" similar, mainly used as antipyretic analgesics, action slow and protracted, have better curative effect on the treatment of headache, neuralgia, arthritis pain and fever, but anti rheumatism, anti-inflammatory effect is weak. Excessive dosage can cause High-speed Rail hemoglobin disorders, resulting in hypoxia, long-term use can damage the kidneys, and even cause papillary necrosis, should be used with caution. Due to the rapid development of its toxic side effects and other similar drugs, the drug has been stopped alone, just as raw materials and other drug compound preparation. Often associated with aspirin, caffeine together form a compound aspirin, which is composed of non phenacetin 0.162 grams, 0.227 grams, 0.035 grams of aspirin, caffeine, low toxicity, for the treatment of colds. Such as the addition of the drug in a small amount of chlorpheniramine, also can be made into chlorpheniramine cold tablets, can be used for the treatment of cold headache, neuralgia, rheumatism and so.
3. non phenacetin in itself is not the antipyretic and analgesic effects, in the body, after metabolism decomposition of acetaminophen or paracetamol, just play the antipyretic and analgesic effect. Also the decomposition of ammonia benzene ether, not only without the antipyretic and analgesic effects of ammonia benzene ether, and is a major factor in toxicity of phenacetin non.
Package: 25kg/drum
Price: USD 6/kg

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