MarketWatch (press release) Suppression of the PGP pump allows certain clinically important compounds (such as Paclitaxel and Irinotecan , among others) which would normally be effluxed back into the gastrointestinal tract and excreted, to enter the bloodstream and be bioavailable ... and more »
Wall Street Journal (press release) ... owing to the launch and rapid uptake of three high-priced agents--Celgene/Taiho's Abraxane, Onconova Therapeutics/Baxter International/SymBio Pharmaceuticals' Estybon and Merrimack Pharmaceuticals' MM-398 (a novel formulation of irinotecan ). and more »
GlobeNewswire (press release) SN-38 is the active form of, and about three orders of magnitude more potent than, irinotecan or CPT-11,an FDA-approved drug for metastatic colorectal cancer treatment. The powerful cancer drug cannot be administered systemically to patients because of ... and more »
General Surgery News The FDA has approved a new use for Avastin (Genentech; bevacizumab) in combination with fluoropyrimidine-based irinotecan or oxaliplatin chemotherapy for use in patients with metastatic colorectal cancer (mCRC). The new indication will allow people ... and more »
Healio Patients assigned to arm A (n=70) received cetuximab and chemotherapy (fluorouracil, leucovorin and irinotecan or modified fluorouracil, leucovorin and oxaliplatin). Patients assigned to arm B (n=68) received chemotherapy alone. The rate of conversion ...
MarketWatch In February 2013, the European Commission (EC) granted marketing authorization in the European Union for ZALTRAP concentrate for solution for infusion in combination with irinotecan /5-fluorouracil/folinic acid (FOLFIRI) chemotherapy in adults with ...
Wall Street Journal (press release) Suppression of the PGP pump allows certain clinically important compounds (such as Paclitaxel and Irinotecan , among others) which would normally be effluxed back into the gastrointestinal tract and excreted, to enter the bloodstream and be bioavailable ... and more »
Business Wire (press release) ... well-known and has been used by the medical community for decades; however the linker has broad potential utility with proven affinity to couple with multiple chemotherapeutic agents including paclitaxel, docetaxel , cisplatin, irinotecan and ... and more »
