Diabetes In Control Subjects in the study either received canagliflozin 300 mg or sitagliptin 100 mg in addition to their metformin + sulfonylurea and data was collected for a 52-week period. A portion of the subjects in the study took a 3-hr frequently sampled mixed-meal ...
4-traders (press release) AstraZeneca and Bristol-Myers Squibb Company today announced results from a Phase III study evaluating dapagliflozin in adult patients with type 2 diabetes who were inadequately controlled on combination treatment with metformin plus sulfonylurea .
Forbes After adjusting for baseline differences, mortality was 58% higher in the sulfonylurea group. (The crude rates were 44.6 deaths per thousand patient-years in th...
Medscape BARCELONA, Spain — First-line therapy with sulfonylureas significantly increases the risk for death in patients with type 2 diabetes when compared with treatment with metformin, a new study shows. Additional research showed that the combination of ...
Healio According to Rury R. Holman, FRCP, director of the University of Oxford Diabetes Trials Unit and honorary consultant physician to the Oxford Radcliffe Hospitals NHS Trust, the effect of the early addition of metformin to sulfonylurea does not appear to ... and more »
Family Practice News Digital Network BARCELONA – It's taken 15 years, but newly released data are finally clearing the last shadow of doubt over metformin's safety in type 2 diabetes. Patients in the groundbreaking U.K. Prospective Diabetes Study (UKPDS) who took the drug along with a ...
Diabetes Health (press release) According to researchers, dapagliflozin, a diabetes drug developed jointly by two pharmaceutical companies has shown significant benefits when teamed with metformin and sulfonylurea . The drug, already available in Europe, is produced by Bristol-Myers ... and more »
MedPage Today “Specifically they recommend that sulfonylureas be avoided in patients with cardiovascular disease risk based on current literature, which [indicates] increased cardiovascular mortality among sulfonylurea users,” he said. He also noted that "there is ... and more »
Monthly Prescribing Reference In the hypoglycemia assessment, patients were analyzed by antidiabetic medication at baseline (not treated with antidiabetic drugs, treated with metformin alone, treated with sulfonylurea , treated with insulin alone or treated with insulin in ...
