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已读[45] 发布: 2013/08/13 16:42:02
PR Newswire (press release) DIFICID, a macrolide antibacterial drug, was approved by the U.S. Food and Drug Administration on May 27, 2011, for the treatment of Clostridium difficile-associated diarrhea, or CDAD, in adults 18 years of age and older. Fidaxomicin has also received  ... and more »
已读[30] 发布: 2013/08/13 16:41:56
Yahoo! New Zealand News The company also intends to use its series of proprietary lead compounds from its novel macrolide library for uses such as the treatment of chronic inflammatory diseases, endocrine diseases and gastric motility disorders. Additional information about ... and more »
已读[43] 发布: 2013/08/13 16:41:51
Seeking Alpha Biocyclolides are a new class of macrolide antibiotics developed by Enanta that have been designed to overcome resistance more effectively than existing macrolide products such as Biaxin or Zithromax. IND-enabling studies are now in progress, and ...
已读[38] 发布: 2013/08/13 16:41:46
DigitalJournal.com (press release) FDA is in the process of updating risk information in the drug labels for additional macrolide antibacterial drugs.” The New England Journal of Medicine study included research compiled from information accumulated from about 350,000 patients who were  ...
已读[34] 发布: 2013/08/13 16:41:40
Corante I am curious to see how it works with cyclic peptides and how it may branch out in to more ' macrolide -like' macrocycles. Permalink to Comment · 7. weirdo on July 25, 2013 4:44 PM writes... OK, OK, I'm not at this conference, so I don't know exactly was ...
已读[30] 发布: 2013/08/13 16:41:35
MarketWatch (press release) About DIFICID� (fidaxomicin) Tablets DIFICID is the first macrolide antibacterial drug indicated for Clostridium difficile-associated diarr...
已读[28] 发布: 2013/08/13 16:41:29
MarketWatch (press release) Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of dihydroergotamine with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP3A4 inhibition elevates the serum  ... and more »
已读[453] 发布: 2013/08/12 08:34:44
    前段时间,美国食品和药物管理局(FDA)发布警告称,抗生素阿奇霉素可导致心脏 活动异常,引起致命性心律失常。如合并QT间期(心脏每起搏一次至下一次起搏所停顿的时间)延长、低钾血症和低镁血症、心动过缓、正在使用抗心律失常药物或心律失常等情况时,使用阿奇霉素发生心律失常风险升高。     可是另一方面,因支原体感染服...
已读[387] 发布: 2013/08/12 08:32:53
两个为期一年的随机临床试验证实,红霉素、阿奇霉素两个大环内酯类抗生素可减轻非囊性纤维化支扩肺感染的急性加剧,但代价是对这两药抗药性增加。 澳大利亚南布里斯班梅特成人医院的David Serisier 及其同事说,在BLESS临床试验中,每日低剂量红霉素维持治疗的病人,其肺感染急性加剧率明显低于使用安慰剂的病人(1.29 vs 1.97人/年,...
已读[2012] 发布: 2013/08/12 08:30:29
       硫氰酸红霉素是大环内酯类原料药的母核,是琥乙红霉素、阿奇霉素、罗红霉素和克拉霉素四大畅销产品的关键中间体原料,在国际市场地位强势。其也是我国大环内酯产品的最大出口品种,近几年一直保持着量价齐升的势头,从2003年600吨左右的出口量到目前增加到3000多吨年出口量,平均价格...
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