FRONTLINE The biology is very difficult to develop completely novel chemical entities that aren't part of existing chemical series like, say, the carbapenems and just optimize your molecules. That's fine; that's the easiest way to go. But to come up with a ...
FRONTLINE The last few years, we've seen resistance to a class of drugs called carbapenems . Ten years ago, carbapenems would be used only as a last resort. Today, carbapenems don't work in treating [resistant] Gram-negative bacteria. There are very, very few ...
FRONTLINE We were down to a family of antibiotics called the carbapenems , which were a very powerful group of antibiotics, and they'd always been our savior when we ne...
7thSpace Interactive (press release) blaOXA-23 was the only acquired carbapenemase gene detected, present in 40 isolates including five carbapenem -susceptible ones. The isolates belonged to 62 pulsotypes determined by PFGE and 31 sequence types (ST) by multi-locus sequence typing.
Minneapolis Star Tribune (blog) Before the year 2000, he said, it was rare to find cases of bacteria resistant to carbapenems , a class of powerful, last-resort antibiotics. But by February 2013 they had been seen in almost every state. Srinivasan also briefed Thomas Frieden, director ...
PR Newswire (press release) This is evident in the case of Klebsiella pneumoniae. Since 2005, there has been a significant decrease of susceptibility to carbapenems in...
