Title: Pregabalin CAS Registry Number: 148553-50-8 CAS Name: (3S)-3-(Aminomethyl)-5-methylhexanoic acid Additional Names: (S)-(+)-4-amino-3-(2methylpropyl)butanoic acid; (S)-(+)-3-isobutyl-g-aminobutyric acid Manufacturers' Codes: CI-1008; PD-144723 Molecular Formula: C8H17NO2 Molecular Weight: 159.23. Percent Composition: C 60.34%, H 10.76%, N 8.80%, O 20.10% Literature References: GABA analog. Prepn of racemate: R. Andruszkiewicz, R. B. Silverman, Synthesis 1989, 953. Enantioselective synthesis: P. Yuen et al., Bioorg. Med. Chem. Lett. 4, 823 (1994). Manufacturing process: M. S. Hoekstra et al., Org. Process Res. Dev. 1, 26 (1997). HPLC determn in biological fluids: B. L. Windsor, L. L. Radulovic, J. Chromatog. B 674, 143 (1995). Anticonvulsive activity: C. P. Taylor et al., Epilepsy Res. 14, 11 (1993). Activity in models of neuropathic pain: M. J. Field et al., Pain 80, 391 (1999). Properties: White crystalline solid, mp 186-188? [a]D23 +10.52?(c = 1.06 in water). Melting point: mp 186-188° Optical Rotation: [a]D23 +10.52?(c = 1.06 in water) Therap-Cat: Anticonvulsant.
