邻甲氧基苯酚 Guaiacol 分子式(Formula)： C7H8O2 分子量(Molecular Weight)： 124.13 CAS No.： 90-05-1 质量指标(Specification) 外观（Appearance）： 白色或浅黄色液体 含量（Purity）： 99% 包装（Package）： 200公斤塑料桶 产地（Orgin）： 上海 物化性质(Physical Properties) 熔点≥26.5℃,干燥后失重 ≤0.5% ,高沸物 ≤0.2 ,茴香醚 0.1-0.2% ,砷含量 ≤0.0003% ,重金属 ≤0.001% 用途(Useage) 是合成多种原料药和香料的重要起始原料 CAS number 90-05-1 Y PubChem 460 ChemSpider 447 Y UNII 6JKA7MAH9C Y KEGG D00117 Y ChEBI CHEBI:28591 Y ChEMBL CHEMBL13766 Molecular formula C7H8O2 Molar mass 124.14 g/mol Density 1.112 g/cm3, liquid 1.129 g/cm3, crystals Melting point 28 °C, 301 K, 82 °F
Boiling point 204–206 °C
Laboratory methodsGuaiacol can be prepared by diverse routes in the laboratory. 2-Aminoanisole, derived in two steps from anisole, can be hydrolyzed via its diazonium derivative. Guaiacol can be synthesized by the dimethylation of catechol followed by selective mono-demethylation.[6]
C6H4(OCH3)2 + C2H5SNa → C6H4(OCH3)(ONa) + C2H5SCH3 PreparationIn industry, guaiacol is produced by methylation of catechol, e.g. using potash and dimethyl sulfate:[5]
Guaiacol is a naturally occurring organic compound with the formula C6H4(OH)(OCH3), discovered by Ascanio Sobrero. Although it is biosynthesized by a variety of organisms, this colorless aromatic oil is usually derived from guaiacum or wood creosote. Samples darken upon exposure to air and light. Guaiacol is present in wood smoke, resulting from the pyrolysis of lignin. The compound contributes to the flavor of many compounds, e.g. roasted coffee.
