对-N咪唑苯甲醛是一种重要的药物中间体,可以用于合成控制人体胆固醇水平的药物。也是一种重要的配位中间体
Ref:
European Journal of Medicinal Chemistry, Volume 44, Issue 11,November 2009, Pages 4654-4660
Tanvir Hussain, Hamid Latif Siddiqui, Muhammad Zia-ur-Rehman, Muhammad Masoom Yasinzai, Masood Parvez
A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities.
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